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When you take Percocet by mouth, it gets absorbed by your gastrointestinal tract Increase the level of oxycodone in your bloodstream and reach within two hours. Pain relief works more efficiently, 10 to 15 minutes after taking Percocet, primarily due to the presence of oxycodone. You will feel sudden pain relief in 30 minutes or 1 hour after a dose. Effects are felt for four to six hours, so the medication is usually prescribed every four to six hours.